That cell proliferation, cell apoptosis and DNA repair may play Improving the sensitivity of human GC cell to DDP is a critical However, the strategy of DDP-based chemotherapy and surgeryĬombination is limited by drug resistance, on the other handĬontinuous and multiple DDP administration often caused serious Rapidly in recent years, cisplatin (DDP) still remains the most
Therefore, the combination of surgeryĪnd chemotherapy is a new strategy for the treatment of GC Currently surgery is the main treatmentįor early GC however recurrence is very common in GC patientsĪfter surgery ( 3, 4). Gastric cancer (GC) is one of the most commonĬancers worldwide, and GC is the 2nd leading cause of cancer death Therefore, our findings suggested miR-34a could modulate human gastric cancer cell DDP sensitivity by regulation of cell proliferation and apoptosis via targeting MET, potentially benefiting human GC treatment in the future. Moreover, our study also indicated that upregulation of miR-34a could decrease the expression of MET in SGC7901/DDP cells. Further study found that MET was a direct target of miR-34a and the regulation of MET could affect the DDP sensitivity of SGC7901/DDP cells. Upregulation of miR-34a enhanced the DDP sensitivity of SGC7901/DDP cells to DDP through the inhibition of cell proliferation and induction of cell apoptosis on the other hand downregulation of miR-34a could weaken the DDP sensitivity of SGC7901 cells to DDP. Our study found that the expression of miR-34a was significantly decreased in DDP resistance human GC tissues and DDP resistance human GC SGC7901/DDP cells compared with normal GC tissues and cells. The purpose of this study was to investigate whether miR-34a is associated with DDP resistance in human GC cells. Previous study also found miR-34a was associated with cell proliferation and apoptosis in human GC however, the relationship between miR-34a and DDP resistance still remains unexplored. Recent studies indicated that the resistance could be modulated by the regulation of dysregulated microRNAs (miRs). However, drug resistance is a major obstacle for DDP chemotherapy. You may notice that this nozzle flow rate is the same as the Stage 1.5 injectors, and if so, good, because they are the same exact nozzle as the Stage 1.5, but the bodies have been "detuned" to lower emissions and EGT's.Cisplatin (DDP) based chemotherapy is still the main strategy of human gastric cancer (GC) treatment. The nozzle flow rate of each injector is set to 96 l/h at a pressure of 100bar, in comparison to the stock injectors that flow at 66 l/h/100bar. These Stage 0.75 injectors from BBi are built to flow an additional 45% over your stock injectors. Big Bang Injection builds new injectors and does not reuse injector parts that are known to fail, hence, why would they want your cores back like everyone else? You will also notice that these injectors do NOT require a core charge like every other manufacturer. That's correct, these injectors will NOT rattle like every other common rail injector on the market. Not only have they accomplished such a feat, but they have identified and cured the common injector rattle issues that have plagued them for years. Further, BBi sought out to correct some of the short falls of the Cummins Common Rail injector that caused premature failures. Every injector is also further tested to ensure an exacting spray angle, as well as equal hole size and pattern to deliver consistent fuel distribution within the piston bowls for a complete combustion. Big Bang Injection has come to market with every intention to dominate.Įach injector set is built with new components and are tested against one another to flow within 2% tolerance of each other to deliver even distribution across the cylinders.
Two years later, after thousands of dynamometer runs, and tens of thousands of street driven miles, BBi is READY. Unable to locate a suitable existing product, Marco sought out, the best of the best, leaders in the field of Common Rail Fuel Injection Technology. Marco clearly saw a need in the aftermarket, for a top shelf injector with consistencies, tolerances and calibrations, as good as, and better, than OEM quality. After extensive testing and research of existing aftermarket performance injector options, none were found to be built to an acceptable standard, when utilized in an extreme performance application.
DDP MASTER OF THE BANG SOFTWARE
With their ties to the infamous Smarty line of tuners and their extreme commitment to building and perfecting the Cummins Common Rail injectors, they have made quite a name for themselves and have lived up to the reputation without flaw.īig Bang Injection was formed at the request of accomplished engine software tuning guru Marco, of MADS Electronics, SMARTY fame. Big Bang Injection is making some big waves within the diesel performance industry.
Precision performance is what you can expect from these hand built injectors for your Commons Rail Cummins.